منابع مشابه
Neurological effects of glutethimide.
Thalidomide in its heyday commonly produced neuropathy. The chemical similarity of the frequently used sedative glutethimide (Doriden) to thalidomide prompted Fullerton and Kremer (1961) to say, 'It is interesting that similar toxic effects have not been reported in patients taking glutethimide . . .'. Since this statement, three authors have reported a total of four cases of nervous system dam...
متن کاملRecovery in severe glutethimide poisoning.
for it was largely intra-thoracic and yet the tear was limited to the oesophago-gastric junction. It is suggested here that there is occasionally a failure of relaxation of the lower oesophagus which raises the pressure gradient to a sufficient degree to cause a tear, for the lower oesophagus normally relaxes during vomiting and in this patient the gastrografin swallow showed evidence of abnorm...
متن کاملOsteomalacia after prolonged glutethimide administration.
Vitamin D deficiency is a previously unreported complication of therapy with hypnotics, and we here report a case of osteomalacia associated with long-term glutethimide administration. There was evidence of pronounced hepatic enzyme induction, and the plasma half-time of (3)H vitamin D(3) was decreased by this drug. In addition, raised levels of serum gamma-glutamyl transpeptidase, 5-nucleotida...
متن کاملSimultaneous spectrophotometric determination of glutethimide and barbiturates.
T HE POSSIBILITY OF DRUG intoxication frequently arises in patients admitted to the hospital in coma. Ingestion of salicylates by children and of barbiturates by adults are the most common causes. Since the introduction of glutethimide (2-ethyl-2-phenylglutarimide) in 1954, there have been increasing reports implicating this drug in drug intoxication. Since the clinical picture of glutethimide ...
متن کاملRapid determination of glutethimide (Doriden) by gas-liquid chromatography.
drugs and nonbarbiturate sedatives, the clinical laboratory has been literally bombarded with requests for special toxicologic analyses. One of the most popular of the nonbarbiturate sedatives is glutethimide (Doriden, Ciba) or -ethyl--phenylglutarimide. This agent has sedative-hypliotic properties and the usual dose is 250-500 mg. taken at bedtime. McBay and Algieri have reported death occurri...
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ژورنال
عنوان ژورنال: BMJ
سال: 1976
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.6042.1014-c